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Handläggning av BK-virus infektion – Bakgrundsdokumentation

Medicinsk Ordbok. Fleroxacin (Fleroxacin). Anti-infektiösa medel, Topoisomeras II- hämmare. Ord Anti-Infective Agents.

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For more information see here. anti-Topoisomerase I antibody, anti-TOP1 antibody, anti-DNA topoisomerase 1 antibody, anti-DNA topoisomerase I antibody, anti-EC 5.99.1.2 antibody, anti-TOPI antibody, anti-topoisomerase (DNA) I antibody, anti-type I DNA topoisomerase antibody Anti-topoisomerase antibodies (ATA) are directed against topoisomerase and found in several diseases, most importantly scleroderma.Diseases with ATA are autoimmune disease because they react with self-proteins. They are also referred to as anti-DNA topoisomerase I antibody (anti-topo I). Use Anti-Topoisomerase II Antibody, clone SWT3D1 (Mouse Monoclonal Antibody) validated in WB, IHC to detect Topoisomerase II also known as DNA topoisomerase 2-alpha. Target description ~175 kDa observed. Uniprot describes 4 isoforms ranging from 174 … Objective: Anti-topoisomerase I (anti-topo I) autoantibodies in systemic sclerosis (SSc) are associated with diffuse skin involvement and interstitial lung fibrosis.

Diseases with ATA are autoimmune disease because they react with self-proteins. They are also referred to as anti-DNA topoisomerase I antibody (anti-topo I). 24 antibodies to Topoisomerase I and validated for use in 7 applications (Immunohistochemistry, Western Blot, Immunoprecipitation, Flow Cytometry, ChIP assay, Immunocytochemistry, Immunofluorescence) INTRODUCTION: In the present study, the detection of anti-topoisomerase I (anti-topo I) autoantibodies was evaluated for diagnosis and risk assessment of systemic sclerosis (SSc) patients in a well characterized large monocentric cohort. 2001-10-01 Serum level of anti-topoisomerase I antibodies is in direct relationship with MPC and PIP joints flexion contractures.

Handläggning av BK-virus infektion – Bakgrundsdokumentation

Reduced DNA topoisomerase II activity and drug-induced DNA cleavage Non-steroidal anti-inflammatory drugs to potentiate chemotherapy effects: from lab to  Identifiering av den nya TAA som ett fragment av humant DNA-topoisomeras I. ( A ) Western blot-analys av anti-SCL-70-autoantikroppreaktionerna med fyra  av B Lytsy · Citerat av 4 — Data från det europeiska organet för övervakning av anti- biotikaförbrukning till minskad affinitet för målenzymerna DNA-gyras och DNA-topoisomeras IV sker i. Studies on the efficacy of potent anti-HIV-1 therapy on virologicaland Topoisomerase II and drug resistance in leukemic cells . Zhou  av B Janicke · 2017 · Citerat av 15 — of the anti‐cancer drug etoposide, a well‐established topoisomerase inhibitor that causes DNA damage and leads to programmed cell death.

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antibody When bacteria enter a flesh wound, a B cell releases antibodies, which attach to the bacteria and direct them toward a macrophage for destruction. Anti-Topoisomerase II alpha antibody (STJ11102067) Western blot analysis of extracts of various cell lines, using p16 ARC Rabbit mAb (STJ11102067) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution.Lysates/proteins: 25ug per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Enhanced Kit.Exposure time: 3min. Antisynthetase syndrome is a set of symptoms that typically occur for patients who have myositis together with one of several specific autoantibodies known as antisynthetase antibodies. Looking for anti-topoisomerase I antibody? Find out information about anti-topoisomerase I antibody. protein produced by the immune system in response to the presence in the body of antigens: foreign proteins or polysaccharides such as bacteria, bacterial Explanation of anti-topoisomerase I antibody Anti-Topoisomerase II alpha + Topoisomerase II beta antibody [EPR5377] browse more products. Anti-alpha 1 Fetoprotein antibody [EP1016Y] | ab52940; Response to Anti-Topoisomerase II Agents Ian G. Cowell * and Caroline A. Austin Institute for Cell and Molecular Biosciences, Newcastle University, Newcastle upon Tyne, Tyne and Wear NE2 4HH, UK; E-Mail: caroline.austin@ncl.ac.uk * Author to whom correspondence should be addressed; E-Mail: ian.cowell@ncl.ac.uk; Type II DNA topoisomerases have the ability to generate a transient DNA double-strand break through which a second duplex can be passed; an activity essential for DNA decatenation and unknotting.

Anti topoisomerase

Topoisomeras I-hämmare Topoisomeras II-hämmare huvudsakligen verka genom anti-angiogenetisk och immunmodulerande/antiinflammatorisk aktivitet. av M Elias · 2017 — Nyckelord. Autoantikroppar, anti-dsDNA, systemisk lupus erythematosus, ELISA, CLIFT, Anti-Sm. Antikroppar mot topoisomeras antigen/Anti scleroderma 70. 2. Raynaud's fenomen, –, 3.
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Anti topoisomerase

The presence of Scl-70 antibodies (also referred to as topoisomerase I, topo-I or ATA) is considered diagnostic for systemic sclerosis (SSc). Scl-70 antibodies alone are detected in about 20 percent of SSc patients and are associated with the diffuse form of the disease, which may include specific organ involvement and poor prognosis. Different antibodies, called anti-topoisomerase and RNA polymerase III, are often present in people who have diffuse systemic sclerosis. Thus, the diagnosis of systemic sclerosis is based on all of the information doctors gather, including symptoms, physical examination results, and all test results. Some antibodies are considered highly specific for SSc, including Scl-70 (anti-topoisomerase 1) antibody, anti-centromere (CENP) antibodies, and anti-RNA polymerase III antibody and are classification criteria for disease defined by the American College of Rheumatology.

Boster Bio Anti-Topoisomerase (DNA) I, Mitochondrial (TOP1MT) Monoclonal Antibody catalog # M09702. Tested in IHC applications.
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Topoisomerases are ubiquitous enzymes necessary for controlling the interlinking and twisting of DNA molecules. Among the four topoisomerases identified in eubacteria, two, DNA gyrase and topoisomerase IV, have been exploited by nature and the pharmaceutical industry as antibacterial targets. Anti-Topoisomerase I-DNA Covalent Complexes Antibody, clone 1.1A is an antibody against Topoisomerase I-DNA Covalent Complexes for use in Immunocytochemistry, Flow Cytometry, Dot Blot, ELISA. Anti-Topoisomerase II Antibody, clone KiS1 is a Mouse Monoclonal Antibody for detection of Topoisomerase II also known as Ki-S1 & has been validated in FC, WB, ICC, IHC, IHC(P).


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Topoisomerase II-alpha expression in different cell cycle

Key words Systemic sclerosis, anti-topoisomerase I antibody, contracture. Clinical and Experimental Rheumatology 2006; 24: 407-412.

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Topoisomerase II is a reported alias name for the human gene TOP2A, or 'DNA topoisomerase II alpha'. The 1531-amino acid protein is a member of the Type II topoisomerase family. The cellular localization is predicted to be cytoplasmic and nuclear.

2009-02-21 Anti‐topoisomerase I auto‐antibodies (ATA) in systemic sclerosis (SSc) are associated with diffuse skin involvement and interstitial lung fibrosis. Thus far, however, the relations between the ATA response and disease course have not yet been fully evaluated.